Neuroprotection and neuroregeneration of retinal ganglion cells after intravitreal carbon monoxide release
نویسندگان
چکیده
منابع مشابه
Neuroprotection and neuroregeneration of retinal ganglion cells after intravitreal carbon monoxide release
PURPOSE Retinal ischemia induces apoptosis leading to neurodegeneration and vision impairment. Carbon monoxide (CO) in gaseous form showed cell-protective and anti-inflammatory effects after retinal ischemia-reperfusion-injury (IRI). These effects were also demonstrated for the intravenously administered CO-releasing molecule (CORM) ALF-186. This article summarizes the results of intravitreally...
متن کاملIntravitreal injection of forskolin, homotaurine, and L-carnosine affords neuroprotection to retinal ganglion cells following retinal ischemic injury
PURPOSE Retinal ganglion cell (RGC) death is the final event leading to visual impairment in glaucoma; therefore, identification of neuroprotective strategies able to slow down or prevent the process is one of the main challenges for glaucoma research. The purpose of this study was to evaluate the neuroprotective potential of RGC death induced by the in vivo transient increase in intraocular pr...
متن کاملTranspupillary thermotherapy: new observations on neuroprotection of retinal ganglion cells.
ranspupillary thermotherapy (TTT) is a technique in which heat s delivered to the posterior segment of the eye through the pupil sing a modified low power diode laser with a broad beam. This ethod uses infrared radiation to increase the temperature in the reated tissue up to 10 ◦C above baseline levels and it is been tried or the treatment of various intraocular tumors and choroidal neoasculari...
متن کاملPreconditioning with inhalative carbon monoxide protects rat retinal ganglion cells from ischemia/reperfusion injury.
PURPOSE. Retinal ischemia/reperfusion (I/R) injury damages retinal neurons. Carbon monoxide (CO) recently attracted attention as cytoprotective because of its anti-inflammatory and antiapoptotic effects. Rapid preconditioning of retinal neurons by inhaled CO before I/R injury may reduce inflammation and apoptosis in retinal ganglion cells (RGCs). METHODS. I/R injury was performed on the left ey...
متن کاملNucleotides in neuroregeneration and neuroprotection
Brain injury generates the release of a multitude of factors including extracellular nucleotides, which exhibit bi-functional properties and contribute to both detrimental actions in the acute phase and also protective and reparative actions in the later recovery phase to allow neuroregeneration. A promising strategy toward restoration of neuronal function is based on activation of endogenous a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS ONE
سال: 2017
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0188444